As a general rule of thumb, ideal ad placement lies in a region balancing the left to right (emphasis towards the left), and top to bottom (emphasis towards the top) portion of a page. Article based pages are an exception, as placing ads directly below an article can lead to a greater number of readers clicking through.
The number of ad units you choose to display can also affect ad performance. While some sites perform well using the maximum 3 ad units per page, it's important to maintain a balance between content and ad display -- the optimal number of ad units per page varies for different sites.
Lastly, remember that custom channels are helpful in the testing process to track ad unit performance. By using channels, you can collect 'before' and 'after' data to help you measure the effects of different ad placements.
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